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性别：男
民族：汉
系所：计算机科学系
职务：计算机科学系主任
职称：教授、学术博导、专业博导、专硕导师
办公电话：
电子邮箱：dapeng.wang@upc.edu.cn
王大鹏
- 个人简介王大鹏，博士，教授，博士生导师。入选山东省泰山学者青年专家。2006年7月毕业于山东大学信息与计算科学专业，获得理学学士学位；2011年7月毕业于中国科学院大学生物信息学专业，获得理学博士学位。2011年到2014年，在中国科学院北京基因组研究所担任助理研究员和副研究员。2014年到2024年，任职于英国伦敦大学学院癌症研究所、英国牛津大学植物科学系、英国利兹大学LeedsOmics、英国牛津大学Wellcome人类遗传学中心和英国帝国理工学院国家心肺研究所。主要从事生物信息学、生物和医学大数据分析、多组学数据整合和数据库构建等方向的研究。担任《Thorax》、《BMC Bioinformatics》等10余家国际期刊编委，主持或者合作参与国家自然科学基金、英国BBSRC、MRC、Royal Society等项目。
通讯地址：山东省青岛市黄岛区长江西路66号工科E座1217室 - 教育经历09/2006 - 07/2011 中国科学院大学，生物信息学，理学博士
09/2002 - 07/2006 山东大学数学与系统科学学院，信息与计算科学，理学学士 - 工作经历09/2024 - 至今 银河电子游戏1331，银河电子游戏1331、银河电子游戏1331，教授
01/2022 - 09/2024 英国帝国理工学院，国家心肺研究所，Research Fellow
01/2021 - 01/2022 英国牛津大学，Wellcome人类遗传学中心，Senior Bioinformatician in Integrative Analysis
02/2018 - 12/2020 英国利兹大学，LeedsOmics，Senior Bioinformatics Research Officer
02/2016 - 01/2018 英国牛津大学，植物科学系，Postdoctoral Research Assistant
03/2014 - 01/2016 英国伦敦大学学院，癌症研究所，Research Associate
01/2014 - 02/2014 中国科学院北京基因组研究所，副研究员
07/2011 - 12/2013 中国科学院北京基因组研究所，助理研究员 - 研究领域生物信息学、计算生物学、人工智能在生物和医学中的应用
- 学术兼职欧洲呼吸学会会员、英国胸科学会会员、英国高等教育学会准会员、英国遗传学会会员、美国胸科学会会员、伦敦数学学会会员
- 教学、科研项目山东省泰山学者青年专家项目，主持
国家自然科学基金青年科学基金项目，主持
中国科学院青年创新促进会会员人才专项经费，主持 - 论文著作1. Tiago H. C. De Bem, Alessandra Bridi, Haidee Tinning, Rafael Vilar Sampaio, Irene Malo-Estepa, Dapeng Wang, Elton J. R. Vasconcelos, Ricardo Perecin Nociti, Ana C. F. C. M. de Ávila, Juliano Rodrigues Sangalli, Igor Garcia Motta, Gilmar Arantes Ataíde Jr, Júlio C. B. da Silva, Yeda Fumie Watanabe, Angela Gonella-Diaza, Juliano C. da Silveira, Guilherme Pugliesi, Flávio Vieira Meirelles, Niamh Forde. Biosensor capability of the endometrium is mediated in part, by altered miRNA cargo from conceptus-derived extracellular vesicles. The FASEB Journal. 2024;38(10):e23639.
2. Rebecca J Brownlie, Ruth Kennedy, Erica B Wilson, Maja Milanovic, Claire F Taylor, Dapeng Wang, John R Davies, Heather Owston, Emma J Adams, Sophie Stephenson, Rebecca Caeser, Benjamin E Gewurz, Peter V Giannoudis, Claudio Scuoppo, Dennis McGonagle, Daniel J Hodson, Reuben M Tooze, Gina M Doody, Gordon Cook, David R Westhead, Ulf Klein. Cytokine receptor IL27RA is an NF-kB-responsive gene involved in CD38 upregulation in multiple myeloma. Blood Advances. 2023;7(15):3874-3890.
3. Amy K. Stainthorp, Chi-Chuan Lin, Dapeng Wang, Ragini Medhi, Zamal Ahmed, Kin Man Suen, Eric A. Miska, Adrian Whitehouse, John E. Ladbury. Regulation of microRNA expression by the adaptor protein GRB2. Scientific Reports. 2023;13(1):9784.
4. Dapeng Wang. Amplicon Sequencing Pipelines in Metagenomics. Methods in Molecular Biology. 2023;2649:69-83.
5. Dapeng Wang. Metagenomics Databases for Bacteria. Methods in Molecular Biology. 2023;2649:55-67.
6. Barry Causier, Mary McKay, Tayah Hopes, James Lloyd, Dapeng Wang, C. Jill Harrison, Brendan Davies. The TOPLESS corepressor regulates developmental switches in the bryophyte Physcomitrium patens that were critical for plant terrestrialisation. The Plant Journal. 2023;115(5):1331-1344.
7. Soo Young Baik, Alisha Maini, Haidee Tinning, Dapeng Wang, Daman J Adlam, Peter T Ruane, Niamh Forde. Transcriptional response of endometrial cells to Insulin, cultured using microfluidics. Reproduction and Fertility. 2023;4(2):e210120.
8. Alysha S. Taylor, Haidee Tinning, Vladimir Ovchinnikov, Jessica Edge, William Smith, Anna L. Pullinger, Ruth A. Sutton, Bede Constantinides, Dapeng Wang, Karen Forbes, Niamh Forde, Mary J. O’Connell. A burst of genomic innovation at the origin of placental mammals mediated embryo implantation. Communications Biology. 2023;6(1):459.
9. Laura Hume, Jessica C. Edge, Haidee Tinning, Dapeng Wang, Alysha S. Taylor, Vladimir Ovchinnikov, Annika V. Geijer-Simpson, Pavle Vrljicak, Jan J. Brosens, Emma S. Lucas, Nigel A.B. Simpson, Jayne Shillito, Karen Forbes, Mary J. O’Connell, Niamh Forde. MicroRNAs emerging coordinate with placental mammals alter pathways in endometrial epithelia important for endometrial function. iScience. 2023;26(4):106339.
10. Dapeng Wang, Vinod Kumar, Katie L Burnham, Alexander J Mentzer, Brian D Marsden, Julian C Knight. COMBATdb: a database for the COVID-19 Multi-Omics Blood ATlas. Nucleic Acids Research. 2023 Jan 6;51(D1):D896-D905.
11. Nunzio D'Agostino, Wenli Li, Dapeng Wang. High-throughput transcriptomics. Scientific Reports. 2022;12(1):20313.
12. Wanda M Waterworth, Rosalind Latham, Dapeng Wang, Mona Alsharif, Christopher E West. Seed DNA damage responses promote germination and growth in Arabidopsis thaliana. Proceedings of the National Academy of Sciences of the United States of America. 2022;119(30):e2202172119.
13. Louise Richardson, Dapeng Wang, Ruth Hughes, Colin A Johnson, Michelle Peckham. RNA-Seq analysis of a Pax3-expressing myoblast clone in-vitro and effect of culture surface stiffness on differentiation. Scientific Reports. 2022;12(1):2841.
14. COvid-19 Multi-omics Blood ATlas (COMBAT) Consortium. A blood atlas of COVID-19 defines hallmarks of disease severity and specificity. Cell. 2022;185(5):916-938.e58. (Member of the COMBAT Consortium)
15. Anthony M Buckley, Ines B Moura, Norie Arai, William Spittal, Emma Clark, Yoshihiro Nishida, Hannah C Harris, Karen Bentley, Georgina Davis, Dapeng Wang, Suparna Mitra, Takanobu Higashiyama, Mark H Wilcox. Trehalose-Induced Remodelling of the Human Microbiota Affects Clostridioides difficile Infection Outcome in an In Vitro Colonic Model: A Pilot Study. Frontiers in Cellular and Infection Microbiology. 2021;11:670935.
16. Katerina Douka, Isabel Birds, Dapeng Wang, Andreas Kosteletos, Sophie Clayton, Abigail Byford, Elton J R Vasconcelos, Mary J O'Connell, Jim Deuchars, Adrian Whitehouse, Julie L Aspden. Cytoplasmic long noncoding RNAs are differentially regulated and translated during human neuronal differentiation. RNA. 2021;27(9):1082-1101.
17. Tiago H C De Bem, Haidee Tinning, Elton J R Vasconcelos, Dapeng Wang, Niamh Forde. Endometrium On-a-Chip Reveals Insulin- and Glucose-induced Alterations in the Transcriptome and Proteomic Secretome. Endocrinology. 2021;162(6):bqab054.
18. Haidee Tinning, Alysha Taylor, Dapeng Wang, Bede Constantinides, Ruth Sutton, Georgios Oikonomou, Miguel A Velazquez, Paul Thompson, Achim Treumann, Mary J O'Connell, Niamh Forde. The role of CAPG in molecular communication between the embryo and the uterine endometrium: Is its function conserved in species with different implantation strategies?. The FASEB Journal. 2020;34(8):11015-11029.
19. Wanda M Waterworth, Michael Wilson, Dapeng Wang, Thomas Nuhse, Stacey Warward, Julian Selley, Christopher E West. Phosphoproteomic analysis reveals plant DNA damage signalling pathways with a functional role for histone H2AX phosphorylation in plant growth under genotoxic stress. The Plant Journal. 2019;100(5):1007-1021.
20. Dapeng Wang. IntronDB: a database for eukaryotic intron features. Bioinformatics. 2019;35(21):4400-4401.
21. Dapeng Wang. hppRNA-a Snakemake-based handy parameter-free pipeline for RNA-Seq analysis of numerous samples. Briefings in Bioinformatics. 2018;19(4):622-626.
22. Dapeng Wang. GCevobase: an evolution-based database for GC content in eukaryotic genomes. Bioinformatics. 2018;34(12):2129-2131.
23. Charlotta Böiers, Simon E Richardson, Emma Laycock, Alya Zriwil, Virginia A Turati, John Brown, Jason P Wray, Dapeng Wang, Chela James, Javier Herrero, Ewa Sitnicka, Stefan Karlsson, Andrew J H Smith, Sten Erik W Jacobsen, Tariq Enver. A Human IPS Model Implicates Embryonic B-Myeloid Fate Restriction as Developmental Susceptibility to B Acute Lymphoblastic Leukemia-Associated ETV6-RUNX1. Developmental Cell. 2018;44(3):362-377.e7.
24. Itaru Kato, Yoko Nishinaka, Masahiro Nakamura, Ayse U Akarca, Akira Niwa, Hiroki Ozawa, Kenichi Yoshida, Makiko Mori, Dapeng Wang, Makiko Morita, Hiroo Ueno, Yusuke Shiozawa, Yuichi Shiraishi, Satoru Miyano, Rajeev Gupta, Katsutsugu Umeda, Kenichiro Watanabe, Katsuyoshi Koh, Souichi Adachi, Toshio Heike, Megumu K Saito, Masashi Sanada, Seishi Ogawa, Teresa Marafioti, Akira Watanabe, Tatsutoshi Nakahata, Tariq Enver. Hypoxic adaptation of leukemic cells infiltrating the CNS affords a therapeutic strategy targeting VEGFA. Blood. 2017;129(23):3126-3129.
25. Dapeng Wang. DLGP: A database for lineage-conserved and lineage-specific gene pairs in animal and plant genomes. Biochemical and Biophysical Research Communications. 2016;469(3):542-545.
26. Dapeng Wang, Jiayue Xu, Jun Yu. KGCAK: a K-mer based database for genome-wide phylogeny and complexity evaluation. Biology Direct. 2015;10:53.
27. Dapeng Wang, Jun Yu. LCGserver: A Webserver for Exploring Evolutionary Trajectory of Gene Orders in a Large Number of Genomes. OMICS: A Journal of Integrative Biology. 2015;19(9):574-577.
28. Cristina Pina, José Teles, Cristina Fugazza, Gillian May, Dapeng Wang, Yanping Guo, Shamit Soneji, John Brown, Patrik Edén, Mattias Ohlsson, Carsten Peterson, Tariq Enver. Single-Cell Network Analysis Identifies DDIT3 as a Nodal Lineage Regulator in Hematopoiesis. Cell Reports. 2015;11(10):1503-1510.
29. Dapeng Wang, Jun Yu. Plastid-LCGbase: a collection of evolutionarily conserved plastid-associated gene pairs. Nucleic Acids Research. 2015;43(Database issue):D990-D995.
30. Dapeng Wang, Yan Xia, Xinna Li, Lixia Hou, Jun Yu. The Rice Genome Knowledgebase (RGKbase): an annotation database for rice comparative genomics and evolutionary biology. Nucleic Acids Research. 2013;41(Database issue):D1199-D1205. - 获得荣誉2023 入选山东省泰山学者青年专家
2013 入选中国科学院青年创新促进会会员
2011 中国科学院院长优秀奖 - 指导学生已指导硕士研究生4名
招生专业：
学术学位博士：软件工程专业
专业学位博士：资源与环境-地质工程专业
学术学位硕士：计算机科学与技术专业
专业学位硕士：计算机技术专业、软件工程专业